Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 5145078..5145817 Replicon chromosome
Accession NZ_CP121127
Organism Klebsiella pneumoniae strain UHD-53_PH

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag P8T39_RS25040 Protein ID WP_032415800.1
Coordinates 5145332..5145817 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag P8T39_RS25035 Protein ID WP_003026799.1
Coordinates 5145078..5145344 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T39_RS25020 (P8T39_25020) 5140581..5142650 + 2070 WP_002922127.1 glycine--tRNA ligase subunit beta -
P8T39_RS25025 (P8T39_25025) 5142947..5144316 + 1370 WP_087830479.1 IS3 family transposase -
P8T39_RS25030 (P8T39_25030) 5144517..5144945 + 429 WP_004901287.1 GFA family protein -
P8T39_RS25035 (P8T39_25035) 5145078..5145344 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
P8T39_RS25040 (P8T39_25040) 5145332..5145817 + 486 WP_032415800.1 GNAT family N-acetyltransferase Toxin
P8T39_RS25045 (P8T39_25045) 5146161..5146313 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
P8T39_RS25050 (P8T39_25050) 5146615..5148234 + 1620 WP_032415799.1 ABC-F family ATP-binding cassette domain-containing protein -
P8T39_RS25055 (P8T39_25055) 5148333..5148545 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P8T39_RS25060 (P8T39_25060) 5148798..5149088 - 291 WP_002921931.1 HTH-type transcriptional regulator -
P8T39_RS25065 (P8T39_25065) 5149334..5150689 - 1356 WP_032415797.1 aromatic acid/H+ symport family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5143591..5144316 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17624.46 Da        Isoelectric Point: 10.1428

>T275713 WP_032415800.1 NZ_CP121127:5145332-5145817 [Klebsiella pneumoniae]
VGRITAPEPLCSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT275713 WP_003026799.1 NZ_CP121127:5145078-5145344 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References