Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4542905..4544586 | Replicon | chromosome |
| Accession | NZ_CP121127 | ||
| Organism | Klebsiella pneumoniae strain UHD-53_PH | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A2L0KL13 |
| Locus tag | P8T39_RS22190 | Protein ID | WP_019704723.1 |
| Coordinates | 4542905..4543822 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | P8T39_RS22195 | Protein ID | WP_032415850.1 |
| Coordinates | 4543828..4544586 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P8T39_RS22170 (P8T39_22170) | 4538211..4539731 | + | 1521 | WP_032415851.1 | sugar ABC transporter ATP-binding protein | - |
| P8T39_RS22175 (P8T39_22175) | 4539728..4540726 | + | 999 | WP_004186549.1 | ribose ABC transporter permease | - |
| P8T39_RS22180 (P8T39_22180) | 4540757..4541698 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| P8T39_RS22185 (P8T39_22185) | 4541773..4542780 | + | 1008 | WP_004178300.1 | carbohydrate kinase family protein | - |
| P8T39_RS22190 (P8T39_22190) | 4542905..4543822 | - | 918 | WP_019704723.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| P8T39_RS22195 (P8T39_22195) | 4543828..4544586 | - | 759 | WP_032415850.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| P8T39_RS22200 (P8T39_22200) | 4544672..4545400 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| P8T39_RS22205 (P8T39_22205) | 4545673..4547820 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| P8T39_RS22210 (P8T39_22210) | 4548050..4548736 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34632.07 Da Isoelectric Point: 5.4707
>T275711 WP_019704723.1 NZ_CP121127:c4543822-4542905 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28521.90 Da Isoelectric Point: 10.0870
>AT275711 WP_032415850.1 NZ_CP121127:c4544586-4543828 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQSQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQSQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|