Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2318600..2320188 Replicon chromosome
Accession NZ_CP121127
Organism Klebsiella pneumoniae strain UHD-53_PH

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P8T39_RS11605 Protein ID WP_032414910.1
Coordinates 2318600..2319922 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag P8T39_RS11610 Protein ID WP_002904790.1
Coordinates 2319922..2320188 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T39_RS11590 (P8T39_11590) 2313656..2316157 + 2502 WP_032414912.1 fimbria/pilus outer membrane usher protein -
P8T39_RS11595 (P8T39_11595) 2316145..2317149 + 1005 WP_004176196.1 fimbrial protein -
P8T39_RS11600 (P8T39_11600) 2317291..2318583 + 1293 WP_032414911.1 glycoside hydrolase family 10 protein -
P8T39_RS11605 (P8T39_11605) 2318600..2319922 - 1323 WP_032414910.1 type II toxin-antitoxin system HipA family toxin Toxin
P8T39_RS11610 (P8T39_11610) 2319922..2320188 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P8T39_RS11615 (P8T39_11615) 2320454..2320780 - 327 WP_032414908.1 hydroxyisourate hydrolase -
P8T39_RS11620 (P8T39_11620) 2320777..2321277 - 501 WP_032414907.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
P8T39_RS11625 (P8T39_11625) 2321255..2322634 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
P8T39_RS11630 (P8T39_11630) 2322980..2324134 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
P8T39_RS11635 (P8T39_11635) 2324115..2325038 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49150.45 Da        Isoelectric Point: 7.5618

>T275707 WP_032414910.1 NZ_CP121127:c2319922-2318600 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGHDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT275707 WP_002904790.1 NZ_CP121127:c2320188-2319922 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References