Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1348149..1348790 Replicon chromosome
Accession NZ_CP121119
Organism Halomonas sp. M1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag P8S54_RS06075 Protein ID WP_281443645.1
Coordinates 1348149..1348331 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P8S54_RS06080 Protein ID WP_281443646.1
Coordinates 1348371..1348790 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8S54_RS06045 (P8S55_06030) 1343352..1344233 + 882 WP_281443643.1 NAD(P)-dependent oxidoreductase -
P8S54_RS06060 (P8S55_06045) 1344908..1346386 - 1479 WP_281443644.1 glutamate--tRNA ligase -
P8S54_RS06065 (P8S55_06050) 1346688..1347212 + 525 WP_009098845.1 helix-turn-helix domain-containing protein -
P8S54_RS06070 (P8S55_06055) 1347233..1347814 - 582 WP_009098846.1 hypothetical protein -
P8S54_RS06075 (P8S55_06060) 1348149..1348331 + 183 WP_281443645.1 type II toxin-antitoxin system HicA family toxin Toxin
P8S54_RS06080 (P8S55_06065) 1348371..1348790 + 420 WP_281443646.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P8S54_RS06085 (P8S55_06070) 1348910..1349059 + 150 WP_281443647.1 hypothetical protein -
P8S54_RS06090 (P8S55_06075) 1349156..1349821 - 666 WP_281443648.1 hypothetical protein -
P8S54_RS06095 (P8S55_06080) 1349811..1350215 - 405 WP_281443649.1 hypothetical protein -
P8S54_RS06100 (P8S55_06085) 1350220..1351332 - 1113 WP_281443650.1 hypothetical protein -
P8S54_RS06105 (P8S55_06090) 1351887..1352918 + 1032 WP_281443651.1 tRNA dihydrouridine(20/20a) synthase DusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6710.81 Da        Isoelectric Point: 11.7334

>T275700 WP_281443645.1 NZ_CP121119:1348149-1348331 [Halomonas sp. M1]
VNSRALIKELEQDGWKLARINGSHHHFRHPNKPGTVTVPHPKKDLKTGLVRGIRKSAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15437.44 Da        Isoelectric Point: 4.3241

>AT275700 WP_281443646.1 NZ_CP121119:1348371-1348790 [Halomonas sp. M1]
MLFPIAIERGDEQHAYGVVVPDLNGCFSAGDTFEEALANVKEAIEGWLEVAVEYGDPIPEAQTIEQHMENPDFEGWIWAV
VDIDLTPYLGKSHKINVTLPDLLVKQIDDYVASHPGDKTRSGFLSRVAMAELARARKRA

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References