Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1091636..1092341 Replicon chromosome
Accession NC_017656
Organism Escherichia coli O55:H7 str. RM12579

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag ECO55CA74_RS05405 Protein ID WP_000539519.1
Coordinates 1091955..1092341 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ECO55CA74_RS05400 Protein ID WP_001280945.1
Coordinates 1091636..1091965 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECO55CA74_RS05385 1086793..1087704 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
ECO55CA74_RS05390 1087882..1090230 + 2349 WP_000950334.1 EAL domain-containing protein -
ECO55CA74_RS05395 1090238..1091566 + 1329 WP_000086905.1 GGDEF domain-containing protein -
ECO55CA74_RS05400 1091636..1091965 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
ECO55CA74_RS05405 1091955..1092341 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECO55CA74_RS05410 1092567..1093892 - 1326 WP_000049364.1 30S ribosomal protein S12 methylthiotransferase RimO -
ECO55CA74_RS05415 1094105..1094488 + 384 WP_000497137.1 biofilm formation regulator BssR -
ECO55CA74_RS05420 1094599..1095714 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
ECO55CA74_RS05425 1095711..1096337 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T27569 WP_000539519.1 NC_017656:c1092341-1091955 [Escherichia coli O55:H7 str. RM12579]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T27569 NC_017656:c1092341-1091955 [Escherichia coli O55:H7 str. RM12579]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT27569 WP_001280945.1 NC_017656:c1091965-1091636 [Escherichia coli O55:H7 str. RM12579]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT27569 NC_017656:c1091965-1091636 [Escherichia coli O55:H7 str. RM12579]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References