Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3299547..3300159 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag P5670_RS16045 Protein ID WP_000833473.1
Coordinates 3299547..3299732 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag P5670_RS16050 Protein ID WP_000499744.1
Coordinates 3299749..3300159 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5670_RS16035 (3296379) 3296379..3297530 + 1152 WP_000741501.1 L-threonine dehydrogenase -
P5670_RS16040 (3297731) 3297731..3299269 + 1539 WP_001309845.1 aldehyde dehydrogenase AldB -
P5670_RS16045 (3299547) 3299547..3299732 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
P5670_RS16050 (3299749) 3299749..3300159 + 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P5670_RS16055 (3300231) 3300231..3302195 - 1965 WP_001026861.1 glycoside hydrolase family 127 protein -
P5670_RS16060 (3302206) 3302206..3303606 - 1401 WP_000204802.1 MFS transporter -
P5670_RS16065 (3303832) 3303832..3304647 + 816 WP_000891825.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T275673 WP_000833473.1 NZ_CP121087:3299547-3299732 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT275673 WP_000499744.1 NZ_CP121087:3299749-3300159 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References