Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2679235..2679732 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag P5670_RS13255 Protein ID WP_001173343.1
Coordinates 2679235..2679408 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag P5670_RS13260 Protein ID WP_000398619.1
Coordinates 2679436..2679732 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5670_RS13245 (2675906) 2675906..2677363 + 1458 WP_000856848.1 dipeptide/tripeptide permease DtpC -
P5670_RS13250 (2677600) 2677600..2679117 + 1518 WP_000003806.1 lysine--tRNA ligase -
P5670_RS13255 (2679235) 2679235..2679408 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
P5670_RS13260 (2679436) 2679436..2679732 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
P5670_RS13265 (2679961) 2679961..2680233 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
P5670_RS13270 (2680245) 2680245..2680475 - 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
P5670_RS13275 (2680656) 2680656..2682287 + 1632 WP_001216477.1 sensor histidine kinase -
P5670_RS13280 (2682284) 2682284..2683003 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T275672 WP_001173343.1 NZ_CP121087:c2679408-2679235 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT275672 WP_000398619.1 NZ_CP121087:c2679732-2679436 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References