Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2579571..2580166 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag P5670_RS12745 Protein ID WP_024190283.1
Coordinates 2579571..2579921 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag P5670_RS12750 Protein ID WP_001223213.1
Coordinates 2579915..2580166 (-) Length 84 a.a.

Genomic Context


P5670_RS12740P5670_RS12725P5670_RS12730P5670_RS12735P5670_RS12745P5670_RS12750P5670_RS12755P5670_RS12760
Location: 2578962..2579492 (531 bp)
Type: Others
Protein ID: WP_000055075.1
Location: 2574945..2575967 (1023 bp)
Type: Others
Protein ID: WP_001298067.1
Location: 2575981..2577483 (1503 bp)
Type: Others
Protein ID: WP_001605422.1
Location: 2577696..2578652 (957 bp)
Type: Others
Protein ID: WP_000265933.1
Location: 2579571..2579921 (351 bp)
Type: Toxin
Protein ID: WP_024190283.1
Location: 2579915..2580166 (252 bp)
Type: Antitoxin
Protein ID: WP_001223213.1
Location: 2580378..2580719 (342 bp)
Type: Others
Protein ID: WP_001219160.1
Location: 2580722..2584501 (3780 bp)
Type: Others
Protein ID: WP_000060904.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
P5670_RS12725 (2574945)2574945..2575967-1023WP_001298067.1ABC transporter permease-
P5670_RS12730 (2575981)2575981..2577483-1503WP_001605422.1sugar ABC transporter ATP-binding protein-
P5670_RS12735 (2577696)2577696..2578652-957WP_000265933.1galactofuranose ABC transporter substrate-binding protein YtfQ-
P5670_RS12740 (2578962)2578962..2579492+531WP_000055075.1inorganic diphosphatase-
P5670_RS12745 (2579571)2579571..2579921-351WP_024190283.1endoribonuclease toxin ChpBToxin
P5670_RS12750 (2579915)2579915..2580166-252WP_001223213.1type II toxin-antitoxin system antitoxin ChpSAntitoxin
P5670_RS12755 (2580378)2580378..2580719-342WP_001219160.1gamma-glutamylcyclotransferase-
P5670_RS12760 (2580722)2580722..2584501-3780WP_000060904.1autotransporter assembly complex protein TamB-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-114)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12423.38 Da        Isoelectric Point: 6.2206

>T275671 WP_024190283.1 NZ_CP121087:c2579921-2579571 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMALVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT275671 WP_001223213.1 NZ_CP121087:c2580166-2579915 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBL4JJX7

References