Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2566710..2567232 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag P5670_RS12680 Protein ID WP_001105433.1
Coordinates 2566710..2567000 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag P5670_RS12685 Protein ID WP_000212715.1
Coordinates 2566990..2567232 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5670_RS12665 (2561873) 2561873..2563528 + 1656 WP_001605425.1 alpha,alpha-phosphotrehalase -
P5670_RS12670 (2563922) 2563922..2566060 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
P5670_RS12675 (2566245) 2566245..2566709 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P5670_RS12680 (2566710) 2566710..2567000 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P5670_RS12685 (2566990) 2566990..2567232 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P5670_RS12690 (2567424) 2567424..2567810 - 387 WP_001232253.1 cytochrome b562 -
P5670_RS12695 (2567865) 2567865..2569217 - 1353 WP_001162171.1 metalloprotease PmbA -
P5670_RS12700 (2569312) 2569312..2569863 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T275670 WP_001105433.1 NZ_CP121087:c2567000-2566710 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT275670 WP_000212715.1 NZ_CP121087:c2567232-2566990 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References