Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1809087..1809705 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P5670_RS09085 Protein ID WP_001291435.1
Coordinates 1809487..1809705 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P5670_RS09080 Protein ID WP_000344800.1
Coordinates 1809087..1809461 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5670_RS09070 (1804176) 1804176..1805369 + 1194 WP_277967473.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P5670_RS09075 (1805392) 1805392..1808541 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
P5670_RS09080 (1809087) 1809087..1809461 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P5670_RS09085 (1809487) 1809487..1809705 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P5670_RS09090 (1809877) 1809877..1810428 + 552 WP_000102559.1 maltose O-acetyltransferase -
P5670_RS09095 (1810544) 1810544..1811014 + 471 WP_000136192.1 YlaC family protein -
P5670_RS09100 (1811178) 1811178..1812728 + 1551 WP_001389864.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P5670_RS09105 (1812770) 1812770..1813123 - 354 WP_000878140.1 DUF1428 domain-containing protein -
P5670_RS09115 (1813502) 1813502..1813813 + 312 WP_000409911.1 MGMT family protein -
P5670_RS09120 (1813844) 1813844..1814416 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T275662 WP_001291435.1 NZ_CP121087:1809487-1809705 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT275662 WP_000344800.1 NZ_CP121087:1809087-1809461 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References