275661

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1320492..1321197 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag P5670_RS06635 Protein ID WP_000539521.1
Coordinates 1320492..1320878 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag P5670_RS06640 Protein ID WP_001280945.1
Coordinates 1320868..1321197 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5670_RS06615 (1316496) 1316496..1317122 + 627 WP_001295292.1 glutathione S-transferase GstB -
P5670_RS06620 (1317119) 1317119..1318234 - 1116 WP_000555038.1 aldose sugar dehydrogenase YliI -
P5670_RS06625 (1318345) 1318345..1318728 - 384 WP_000497137.1 biofilm formation regulator BssR -
P5670_RS06630 (1318941) 1318941..1320266 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
P5670_RS06635 (1320492) 1320492..1320878 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P5670_RS06640 (1320868) 1320868..1321197 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
P5670_RS06645 (1321267) 1321267..1322595 - 1329 WP_000086879.1 GGDEF domain-containing protein -
P5670_RS06650 (1322603) 1322603..1324951 - 2349 WP_001322378.1 EAL domain-containing protein -
P5670_RS06655 (1325129) 1325129..1326040 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T275661 WP_000539521.1 NZ_CP121087:1320492-1320878 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT275661 WP_001280945.1 NZ_CP121087:1320868-1321197 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References