275659

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 728012..728650 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name hicA Uniprot ID B7N4J4
Locus tag P5670_RS03660 Protein ID WP_000813797.1
Coordinates 728474..728650 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P5670_RS03655 Protein ID WP_076611057.1
Coordinates 728012..728428 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5670_RS03635 (723164) 723164..724105 - 942 WP_001251335.1 ABC transporter permease -
P5670_RS03640 (724106) 724106..725119 - 1014 WP_000220413.1 ABC transporter ATP-binding protein -
P5670_RS03645 (725137) 725137..726282 - 1146 WP_000047447.1 ABC transporter substrate-binding protein -
P5670_RS03650 (726527) 726527..727933 - 1407 WP_000760613.1 PLP-dependent aminotransferase family protein -
P5670_RS03655 (728012) 728012..728428 - 417 WP_076611057.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
P5670_RS03660 (728474) 728474..728650 - 177 WP_000813797.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
P5670_RS03665 (728872) 728872..729102 + 231 WP_000494244.1 YncJ family protein -
P5670_RS03670 (729194) 729194..731155 - 1962 WP_001309488.1 23S rRNA 5-hydroxycytidine C2501 synthase -
P5670_RS03675 (731228) 731228..731764 - 537 WP_000429161.1 DNA-binding transcriptional regulator SutR -
P5670_RS03680 (731856) 731856..733028 + 1173 WP_001236223.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.76 Da        Isoelectric Point: 11.5666

>T275659 WP_000813797.1 NZ_CP121087:c728650-728474 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15251.65 Da        Isoelectric Point: 4.5908

>AT275659 WP_076611057.1 NZ_CP121087:c728428-728012 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J715

Antitoxin

Source ID Structure

References