275657

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 628277..629865 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name hipA Uniprot ID U9YVT8
Locus tag P5670_RS03215 Protein ID WP_001125415.1
Coordinates 628543..629865 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag P5670_RS03210 Protein ID WP_001296726.1
Coordinates 628277..628543 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5670_RS03210 (628277) 628277..628543 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P5670_RS03215 (628543) 628543..629865 + 1323 WP_001125415.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
P5670_RS03220 (630263) 630263..631162 - 900 WP_001057776.1 LysR family transcriptional regulator -
P5670_RS03225 (631302) 631302..631610 + 309 WP_001221046.1 hypothetical protein -
P5670_RS03230 (631619) 631619..632308 + 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
P5670_RS03235 (632382) 632382..633329 + 948 WP_000854796.1 aldo/keto reductase -
P5670_RS03240 (633432) 633432..633587 + 156 WP_001322415.1 hypothetical protein -
P5670_RS03245 (633547) 633547..633966 + 420 WP_001322416.1 amidohydrolase family protein -
P5670_RS03250 (633956) 633956..634108 + 153 WP_001322417.1 amidohydrolase family protein -
P5670_RS03255 (634259) 634259..634831 + 573 WP_000789913.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49384.05 Da        Isoelectric Point: 8.5830

>T275657 WP_001125415.1 NZ_CP121087:628543-629865 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT275657 WP_001296726.1 NZ_CP121087:628277-628543 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YVT8

Antitoxin

Source ID Structure

References