Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 54779..55329 | Replicon | chromosome |
Accession | NC_017656 | ||
Organism | Escherichia coli O55:H7 str. RM12579 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | D3H432 |
Locus tag | ECO55CA74_RS00270 | Protein ID | WP_001160975.1 |
Coordinates | 55015..55329 (+) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V0VEX8 |
Locus tag | ECO55CA74_RS00265 | Protein ID | WP_000125566.1 |
Coordinates | 54779..55012 (+) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ECO55CA74_RS00240 | 49853..50140 | + | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
ECO55CA74_RS00245 | 50198..51529 | + | 1332 | WP_001183177.1 | MFS transporter | - |
ECO55CA74_RS00250 | 51637..52167 | + | 531 | WP_000600725.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
ECO55CA74_RS00255 | 52160..54022 | + | 1863 | WP_000377186.1 | glutathione-regulated potassium-efflux system protein KefC | - |
ECO55CA74_RS00260 | 54214..54693 | + | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
ECO55CA74_RS00265 | 54779..55012 | + | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
ECO55CA74_RS00270 | 55015..55329 | + | 315 | WP_001160975.1 | CcdB family protein | Toxin |
ECO55CA74_RS00275 | 55326..56174 | - | 849 | WP_000257187.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
ECO55CA74_RS00280 | 56181..56558 | - | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
ECO55CA74_RS00285 | 56561..57382 | - | 822 | WP_001065380.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
ECO55CA74_RS00290 | 57379..58368 | - | 990 | WP_000241259.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
ECO55CA74_RS00295 | 58368..59654 | - | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11711.76 Da Isoelectric Point: 9.8517
>T27565 WP_001160975.1 NC_017656:55015-55329 [Escherichia coli O55:H7 str. RM12579]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
>T27565 NC_017656:55015-55329 [Escherichia coli O55:H7 str. RM12579]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8530.53 Da Isoelectric Point: 5.8062
>AT27565 WP_000125566.1 NC_017656:54779-55012 [Escherichia coli O55:H7 str. RM12579]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
Download Length: 234 bp
>AT27565 NC_017656:54779-55012 [Escherichia coli O55:H7 str. RM12579]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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