Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DinJ
Location 4343472..4343988 Replicon chromosome
Accession NZ_CP121075
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.2574

Toxin (Protein)


Gene name relE Uniprot ID A0A623NIH5
Locus tag P8I05_RS21060 Protein ID WP_023993574.1
Coordinates 4343472..4343756 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A633LVJ8
Locus tag P8I05_RS21065 Protein ID WP_023993575.1
Coordinates 4343746..4343988 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I05_RS21045 (4338588) 4338588..4340240 + 1653 WP_023993572.1 alpha,alpha-phosphotrehalase -
P8I05_RS21050 (4340649) 4340649..4342787 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P8I05_RS21055 (4343004) 4343004..4343468 + 465 WP_023993573.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P8I05_RS21060 (4343472) 4343472..4343756 - 285 WP_023993574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8I05_RS21065 (4343746) 4343746..4343988 - 243 WP_023993575.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P8I05_RS21070 (4344066) 4344066..4345979 - 1914 WP_023993576.1 BglG family transcription antiterminator -
P8I05_RS21075 (4345996) 4345996..4346736 - 741 WP_023993577.1 KDGP aldolase family protein -
P8I05_RS21080 (4346733) 4346733..4347851 - 1119 WP_023993578.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P8I05_RS21085 (4347835) 4347835..4348968 - 1134 WP_023993579.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10925.70 Da        Isoelectric Point: 9.8739

>T275631 WP_023993574.1 NZ_CP121075:c4343756-4343472 [Salmonella enterica subsp. enterica serovar Infantis]
MNYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8989.40 Da        Isoelectric Point: 5.0807

>AT275631 WP_023993575.1 NZ_CP121075:c4343988-4343746 [Salmonella enterica subsp. enterica serovar Infantis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTLTLSDSEDALIQTVRERLSSPQKGIKVSLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623NIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A633LVJ8

References