Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3677072..3677692 Replicon chromosome
Accession NZ_CP121075
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.2574

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P8I05_RS17960 Protein ID WP_001280991.1
Coordinates 3677474..3677692 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P8I05_RS17955 Protein ID WP_000344807.1
Coordinates 3677072..3677446 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I05_RS17945 (3672211) 3672211..3673404 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P8I05_RS17950 (3673427) 3673427..3676576 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P8I05_RS17955 (3677072) 3677072..3677446 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P8I05_RS17960 (3677474) 3677474..3677692 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P8I05_RS17965 (3677871) 3677871..3678422 + 552 WP_001278793.1 maltose O-acetyltransferase -
P8I05_RS17970 (3678540) 3678540..3679010 + 471 WP_000136183.1 YlaC family protein -
P8I05_RS17975 (3679066) 3679066..3679206 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P8I05_RS17980 (3679212) 3679212..3679472 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P8I05_RS17985 (3679697) 3679697..3681247 + 1551 WP_000213140.1 EAL domain-containing protein -
P8I05_RS17995 (3681478) 3681478..3681867 + 390 WP_000961285.1 MGMT family protein -
P8I05_RS18000 (3681900) 3681900..3682469 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T275628 WP_001280991.1 NZ_CP121075:3677474-3677692 [Salmonella enterica subsp. enterica serovar Infantis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT275628 WP_000344807.1 NZ_CP121075:3677072-3677446 [Salmonella enterica subsp. enterica serovar Infantis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References