Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2641692..2642214 Replicon chromosome
Accession NZ_CP121075
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.2574

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag P8I05_RS12750 Protein ID WP_000221343.1
Coordinates 2641930..2642214 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5X3FYG4
Locus tag P8I05_RS12745 Protein ID WP_000885426.1
Coordinates 2641692..2641940 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I05_RS12715 (2637116) 2637116..2638096 - 981 WP_023993266.1 nitronate monooxygenase -
P8I05_RS12720 (2638270) 2638270..2639178 - 909 WP_023994284.1 LysR family transcriptional regulator -
P8I05_RS12725 (2640084) 2640084..2640530 + 447 Protein_2472 helix-turn-helix domain-containing protein -
P8I05_RS12730 (2640529) 2640529..2640723 - 195 Protein_2473 hypothetical protein -
P8I05_RS12735 (2641003) 2641003..2641335 - 333 WP_000253154.1 DUF1493 family protein -
P8I05_RS12740 (2641325) 2641325..2641540 - 216 WP_023993263.1 phage protein -
P8I05_RS12745 (2641692) 2641692..2641940 + 249 WP_000885426.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P8I05_RS12750 (2641930) 2641930..2642214 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8I05_RS12755 (2642385) 2642385..2642774 + 390 WP_023993262.1 RidA family protein -
P8I05_RS12760 (2642822) 2642822..2643901 - 1080 WP_023993261.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
P8I05_RS12765 (2644094) 2644094..2644582 - 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
P8I05_RS12770 (2644627) 2644627..2646135 + 1509 WP_023993260.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2635387..2648992 13605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T275627 WP_000221343.1 NZ_CP121075:2641930-2642214 [Salmonella enterica subsp. enterica serovar Infantis]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9947

>AT275627 WP_000885426.1 NZ_CP121075:2641692-2641940 [Salmonella enterica subsp. enterica serovar Infantis]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3FYG4

References