Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1175978..1176638 Replicon chromosome
Accession NZ_CP121075
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.2574

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I5GR00
Locus tag P8I05_RS05695 Protein ID WP_000244761.1
Coordinates 1176225..1176638 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag P8I05_RS05690 Protein ID WP_000351186.1
Coordinates 1175978..1176244 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I05_RS05670 (1171907) 1171907..1173340 - 1434 WP_001230139.1 6-phospho-beta-glucosidase BglA -
P8I05_RS05675 (1173498) 1173498..1173809 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
P8I05_RS05680 (1173973) 1173973..1174632 + 660 WP_000250289.1 hemolysin III family protein -
P8I05_RS05685 (1174748) 1174748..1175728 - 981 WP_023260866.1 tRNA-modifying protein YgfZ -
P8I05_RS05690 (1175978) 1175978..1176244 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
P8I05_RS05695 (1176225) 1176225..1176638 + 414 WP_000244761.1 protein YgfX Toxin
P8I05_RS05700 (1176691) 1176691..1177212 - 522 WP_001055885.1 flavodoxin FldB -
P8I05_RS05705 (1177325) 1177325..1178221 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
P8I05_RS05710 (1178245) 1178245..1178958 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P8I05_RS05715 (1178964) 1178964..1180697 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16199.15 Da        Isoelectric Point: 10.7537

>T275621 WP_000244761.1 NZ_CP121075:1176225-1176638 [Salmonella enterica subsp. enterica serovar Infantis]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT275621 WP_000351186.1 NZ_CP121075:1175978-1176244 [Salmonella enterica subsp. enterica serovar Infantis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5GR00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References