Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 534985..535745 | Replicon | chromosome |
| Accession | NZ_CP121075 | ||
| Organism | Salmonella enterica subsp. enterica serovar Infantis strain R22.2574 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q57IH1 |
| Locus tag | P8I05_RS02595 | Protein ID | WP_000533909.1 |
| Coordinates | 535260..535745 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | M7RHS4 |
| Locus tag | P8I05_RS02590 | Protein ID | WP_000965886.1 |
| Coordinates | 534985..535272 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P8I05_RS02570 (531688) | 531688..532116 | + | 429 | Protein_492 | IS3 family transposase | - |
| P8I05_RS02575 (532235) | 532235..532885 | - | 651 | WP_023993641.1 | GntR family transcriptional regulator | - |
| P8I05_RS02580 (532970) | 532970..534172 | + | 1203 | WP_023201740.1 | MFS transporter | - |
| P8I05_RS02585 (534261) | 534261..534819 | + | 559 | Protein_495 | cysteine hydrolase | - |
| P8I05_RS02590 (534985) | 534985..535272 | + | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
| P8I05_RS02595 (535260) | 535260..535745 | + | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
| P8I05_RS02600 (536117) | 536117..536656 | - | 540 | WP_000047148.1 | copper-binding periplasmic metallochaperone CueP | - |
| P8I05_RS02605 (536830) | 536830..537042 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| P8I05_RS02610 (537330) | 537330..537620 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| P8I05_RS02615 (538059) | 538059..538769 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| P8I05_RS02620 (538819) | 538819..539793 | - | 975 | WP_023198076.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| P8I05_RS02625 (540012) | 540012..540674 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T275619 WP_000533909.1 NZ_CP121075:535260-535745 [Salmonella enterica subsp. enterica serovar Infantis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT275619 WP_000965886.1 NZ_CP121075:534985-535272 [Salmonella enterica subsp. enterica serovar Infantis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7F36 | |
| PDB | 7AK8 | |
| PDB | 5FVJ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V2JDX2 |