Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 534985..535745 Replicon chromosome
Accession NZ_CP121075
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.2574

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag P8I05_RS02595 Protein ID WP_000533909.1
Coordinates 535260..535745 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag P8I05_RS02590 Protein ID WP_000965886.1
Coordinates 534985..535272 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I05_RS02570 (531688) 531688..532116 + 429 Protein_492 IS3 family transposase -
P8I05_RS02575 (532235) 532235..532885 - 651 WP_023993641.1 GntR family transcriptional regulator -
P8I05_RS02580 (532970) 532970..534172 + 1203 WP_023201740.1 MFS transporter -
P8I05_RS02585 (534261) 534261..534819 + 559 Protein_495 cysteine hydrolase -
P8I05_RS02590 (534985) 534985..535272 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
P8I05_RS02595 (535260) 535260..535745 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
P8I05_RS02600 (536117) 536117..536656 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
P8I05_RS02605 (536830) 536830..537042 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P8I05_RS02610 (537330) 537330..537620 - 291 WP_000455790.1 HTH-type transcriptional regulator -
P8I05_RS02615 (538059) 538059..538769 + 711 WP_000190524.1 DUF3053 domain-containing protein -
P8I05_RS02620 (538819) 538819..539793 - 975 WP_023198076.1 glyoxylate/hydroxypyruvate reductase GhrB -
P8I05_RS02625 (540012) 540012..540674 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T275619 WP_000533909.1 NZ_CP121075:535260-535745 [Salmonella enterica subsp. enterica serovar Infantis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT275619 WP_000965886.1 NZ_CP121075:534985-535272 [Salmonella enterica subsp. enterica serovar Infantis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References