Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DinJ
Location 4183125..4183641 Replicon chromosome
Accession NZ_CP121073
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.2169

Toxin (Protein)


Gene name relE Uniprot ID A0A623NIH5
Locus tag P8I07_RS20455 Protein ID WP_023993574.1
Coordinates 4183125..4183409 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A633LVJ8
Locus tag P8I07_RS20460 Protein ID WP_023993575.1
Coordinates 4183399..4183641 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I07_RS20440 (4178241) 4178241..4179893 + 1653 WP_023993572.1 alpha,alpha-phosphotrehalase -
P8I07_RS20445 (4180302) 4180302..4182440 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P8I07_RS20450 (4182657) 4182657..4183121 + 465 WP_023993573.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P8I07_RS20455 (4183125) 4183125..4183409 - 285 WP_023993574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8I07_RS20460 (4183399) 4183399..4183641 - 243 WP_023993575.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P8I07_RS20465 (4183719) 4183719..4185632 - 1914 WP_023993576.1 BglG family transcription antiterminator -
P8I07_RS20470 (4185649) 4185649..4186389 - 741 WP_023993577.1 KDGP aldolase family protein -
P8I07_RS20475 (4186386) 4186386..4187504 - 1119 WP_023993578.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P8I07_RS20480 (4187488) 4187488..4188621 - 1134 WP_023993579.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10925.70 Da        Isoelectric Point: 9.8739

>T275610 WP_023993574.1 NZ_CP121073:c4183409-4183125 [Salmonella enterica subsp. enterica serovar Infantis]
MNYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8989.40 Da        Isoelectric Point: 5.0807

>AT275610 WP_023993575.1 NZ_CP121073:c4183641-4183399 [Salmonella enterica subsp. enterica serovar Infantis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTLTLSDSEDALIQTVRERLSSPQKGIKVSLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623NIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A633LVJ8

References