Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3516622..3517242 Replicon chromosome
Accession NZ_CP121073
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.2169

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P8I07_RS17355 Protein ID WP_001280991.1
Coordinates 3517024..3517242 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P8I07_RS17350 Protein ID WP_000344807.1
Coordinates 3516622..3516996 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I07_RS17340 (3511761) 3511761..3512954 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P8I07_RS17345 (3512977) 3512977..3516126 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P8I07_RS17350 (3516622) 3516622..3516996 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P8I07_RS17355 (3517024) 3517024..3517242 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P8I07_RS17360 (3517421) 3517421..3517972 + 552 WP_001278793.1 maltose O-acetyltransferase -
P8I07_RS17365 (3518090) 3518090..3518560 + 471 WP_000136183.1 YlaC family protein -
P8I07_RS17370 (3518616) 3518616..3518756 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P8I07_RS17375 (3518762) 3518762..3519022 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P8I07_RS17380 (3519247) 3519247..3520797 + 1551 WP_000213140.1 EAL domain-containing protein -
P8I07_RS17390 (3521028) 3521028..3521417 + 390 WP_000961285.1 MGMT family protein -
P8I07_RS17395 (3521450) 3521450..3522019 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T275607 WP_001280991.1 NZ_CP121073:3517024-3517242 [Salmonella enterica subsp. enterica serovar Infantis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT275607 WP_000344807.1 NZ_CP121073:3516622-3516996 [Salmonella enterica subsp. enterica serovar Infantis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References