275602

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2298431..2298953 Replicon chromosome
Accession NZ_CP121073
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.2169

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag P8I07_RS11225 Protein ID WP_000221343.1
Coordinates 2298431..2298715 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5X3FYG4
Locus tag P8I07_RS11230 Protein ID WP_000885426.1
Coordinates 2298705..2298953 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I07_RS11205 (2294510) 2294510..2296018 - 1509 WP_023993260.1 FAD-dependent oxidoreductase -
P8I07_RS11210 (2296063) 2296063..2296551 + 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
P8I07_RS11215 (2296744) 2296744..2297823 + 1080 WP_023993261.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
P8I07_RS11220 (2297871) 2297871..2298260 - 390 WP_023993262.1 RidA family protein -
P8I07_RS11225 (2298431) 2298431..2298715 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8I07_RS11230 (2298705) 2298705..2298953 - 249 WP_000885426.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P8I07_RS11235 (2299105) 2299105..2299320 + 216 WP_023993263.1 phage protein -
P8I07_RS11240 (2299310) 2299310..2299642 + 333 WP_000253154.1 DUF1493 family protein -
P8I07_RS11245 (2299922) 2299922..2300116 + 195 Protein_2203 hypothetical protein -
P8I07_RS11250 (2300115) 2300115..2300561 - 447 Protein_2204 helix-turn-helix domain-containing protein -
P8I07_RS11255 (2301467) 2301467..2302375 + 909 WP_242211998.1 LysR family transcriptional regulator -
P8I07_RS11260 (2302549) 2302549..2303529 + 981 WP_023993266.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2293073..2305258 12185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T275602 WP_000221343.1 NZ_CP121073:c2298715-2298431 [Salmonella enterica subsp. enterica serovar Infantis]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9947

>AT275602 WP_000885426.1 NZ_CP121073:c2298953-2298705 [Salmonella enterica subsp. enterica serovar Infantis]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3FYG4

References