Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DinJ
Location 4183368..4183884 Replicon chromosome
Accession NZ_CP121070
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.0044

Toxin (Protein)


Gene name relE Uniprot ID A0A623NIH5
Locus tag P8I10_RS20445 Protein ID WP_023993574.1
Coordinates 4183368..4183652 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A633LVJ8
Locus tag P8I10_RS20450 Protein ID WP_023993575.1
Coordinates 4183642..4183884 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I10_RS20430 (4178484) 4178484..4180136 + 1653 WP_023993572.1 alpha,alpha-phosphotrehalase -
P8I10_RS20435 (4180545) 4180545..4182683 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P8I10_RS20440 (4182900) 4182900..4183364 + 465 WP_023993573.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P8I10_RS20445 (4183368) 4183368..4183652 - 285 WP_023993574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8I10_RS20450 (4183642) 4183642..4183884 - 243 WP_023993575.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P8I10_RS20455 (4183962) 4183962..4185875 - 1914 WP_023993576.1 BglG family transcription antiterminator -
P8I10_RS20460 (4185892) 4185892..4186632 - 741 WP_023993577.1 KDGP aldolase family protein -
P8I10_RS20465 (4186629) 4186629..4187747 - 1119 WP_023993578.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P8I10_RS20470 (4187731) 4187731..4188864 - 1134 WP_023993579.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10925.70 Da        Isoelectric Point: 9.8739

>T275589 WP_023993574.1 NZ_CP121070:c4183652-4183368 [Salmonella enterica subsp. enterica serovar Infantis]
MNYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8989.40 Da        Isoelectric Point: 5.0807

>AT275589 WP_023993575.1 NZ_CP121070:c4183884-4183642 [Salmonella enterica subsp. enterica serovar Infantis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTLTLSDSEDALIQTVRERLSSPQKGIKVSLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623NIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A633LVJ8

References