Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3516865..3517485 Replicon chromosome
Accession NZ_CP121070
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.0044

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P8I10_RS17345 Protein ID WP_001280991.1
Coordinates 3517267..3517485 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P8I10_RS17340 Protein ID WP_000344807.1
Coordinates 3516865..3517239 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I10_RS17330 (3512004) 3512004..3513197 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P8I10_RS17335 (3513220) 3513220..3516369 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P8I10_RS17340 (3516865) 3516865..3517239 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P8I10_RS17345 (3517267) 3517267..3517485 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P8I10_RS17350 (3517664) 3517664..3518215 + 552 WP_001278793.1 maltose O-acetyltransferase -
P8I10_RS17355 (3518333) 3518333..3518803 + 471 WP_000136183.1 YlaC family protein -
P8I10_RS17360 (3518859) 3518859..3518999 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P8I10_RS17365 (3519005) 3519005..3519265 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P8I10_RS17370 (3519490) 3519490..3521040 + 1551 WP_000213140.1 EAL domain-containing protein -
P8I10_RS17380 (3521271) 3521271..3521660 + 390 WP_000961285.1 MGMT family protein -
P8I10_RS17385 (3521693) 3521693..3522262 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T275586 WP_001280991.1 NZ_CP121070:3517267-3517485 [Salmonella enterica subsp. enterica serovar Infantis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT275586 WP_000344807.1 NZ_CP121070:3516865-3517239 [Salmonella enterica subsp. enterica serovar Infantis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References