Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 204297..205057 | Replicon | chromosome |
| Accession | NZ_CP121070 | ||
| Organism | Salmonella enterica subsp. enterica serovar Infantis strain R22.0044 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q57IH1 |
| Locus tag | P8I10_RS00955 | Protein ID | WP_000533909.1 |
| Coordinates | 204572..205057 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | M7RHS4 |
| Locus tag | P8I10_RS00950 | Protein ID | WP_000965886.1 |
| Coordinates | 204297..204584 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P8I10_RS00930 (201000) | 201000..201428 | + | 429 | Protein_184 | IS3 family transposase | - |
| P8I10_RS00935 (201547) | 201547..202197 | - | 651 | WP_023993641.1 | GntR family transcriptional regulator | - |
| P8I10_RS00940 (202282) | 202282..203484 | + | 1203 | WP_023201740.1 | MFS transporter | - |
| P8I10_RS00945 (203573) | 203573..204131 | + | 559 | Protein_187 | cysteine hydrolase | - |
| P8I10_RS00950 (204297) | 204297..204584 | + | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
| P8I10_RS00955 (204572) | 204572..205057 | + | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
| P8I10_RS00960 (205429) | 205429..205968 | - | 540 | WP_000047148.1 | copper-binding periplasmic metallochaperone CueP | - |
| P8I10_RS00965 (206142) | 206142..206354 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| P8I10_RS00970 (206642) | 206642..206932 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| P8I10_RS00975 (207371) | 207371..208081 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| P8I10_RS00980 (208131) | 208131..209105 | - | 975 | WP_023198076.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| P8I10_RS00985 (209324) | 209324..209986 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T275575 WP_000533909.1 NZ_CP121070:204572-205057 [Salmonella enterica subsp. enterica serovar Infantis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT275575 WP_000965886.1 NZ_CP121070:204297-204584 [Salmonella enterica subsp. enterica serovar Infantis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7F36 | |
| PDB | 7AK8 | |
| PDB | 5FVJ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V2JDX2 |