Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3523093..3523713 Replicon chromosome
Accession NZ_CP121068
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.1575

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P8I08_RS17385 Protein ID WP_001280991.1
Coordinates 3523495..3523713 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P8I08_RS17380 Protein ID WP_000344807.1
Coordinates 3523093..3523467 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I08_RS17370 (3518232) 3518232..3519425 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P8I08_RS17375 (3519448) 3519448..3522597 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P8I08_RS17380 (3523093) 3523093..3523467 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P8I08_RS17385 (3523495) 3523495..3523713 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P8I08_RS17390 (3523892) 3523892..3524443 + 552 WP_001278793.1 maltose O-acetyltransferase -
P8I08_RS17395 (3524561) 3524561..3525031 + 471 WP_000136183.1 YlaC family protein -
P8I08_RS17400 (3525087) 3525087..3525227 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P8I08_RS17405 (3525233) 3525233..3525493 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P8I08_RS17410 (3525718) 3525718..3527268 + 1551 WP_000213140.1 EAL domain-containing protein -
P8I08_RS17420 (3527499) 3527499..3527888 + 390 WP_000961285.1 MGMT family protein -
P8I08_RS17425 (3527921) 3527921..3528490 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T275565 WP_001280991.1 NZ_CP121068:3523495-3523713 [Salmonella enterica subsp. enterica serovar Infantis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT275565 WP_000344807.1 NZ_CP121068:3523093-3523467 [Salmonella enterica subsp. enterica serovar Infantis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References