275560

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2304902..2305424 Replicon chromosome
Accession NZ_CP121068
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.1575

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag P8I08_RS11255 Protein ID WP_000221343.1
Coordinates 2304902..2305186 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5X3FYG4
Locus tag P8I08_RS11260 Protein ID WP_000885426.1
Coordinates 2305176..2305424 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I08_RS11235 (2300981) 2300981..2302489 - 1509 WP_023993260.1 FAD-dependent oxidoreductase -
P8I08_RS11240 (2302534) 2302534..2303022 + 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
P8I08_RS11245 (2303215) 2303215..2304294 + 1080 WP_023993261.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
P8I08_RS11250 (2304342) 2304342..2304731 - 390 WP_023993262.1 RidA family protein -
P8I08_RS11255 (2304902) 2304902..2305186 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8I08_RS11260 (2305176) 2305176..2305424 - 249 WP_000885426.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P8I08_RS11265 (2305576) 2305576..2305791 + 216 WP_023993263.1 phage protein -
P8I08_RS11270 (2305781) 2305781..2306113 + 333 WP_000253154.1 DUF1493 family protein -
P8I08_RS11275 (2306393) 2306393..2306587 + 195 Protein_2209 hypothetical protein -
P8I08_RS11280 (2306586) 2306586..2307032 - 447 Protein_2210 helix-turn-helix domain-containing protein -
P8I08_RS11285 (2307938) 2307938..2308846 + 909 WP_242211998.1 LysR family transcriptional regulator -
P8I08_RS11290 (2309020) 2309020..2310000 + 981 WP_023993266.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2299544..2311729 12185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T275560 WP_000221343.1 NZ_CP121068:c2305186-2304902 [Salmonella enterica subsp. enterica serovar Infantis]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9947

>AT275560 WP_000885426.1 NZ_CP121068:c2305424-2305176 [Salmonella enterica subsp. enterica serovar Infantis]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3FYG4

References