Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1570505..1571148 Replicon chromosome
Accession NZ_CP121068
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.1575

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag P8I08_RS07545 Protein ID WP_001044768.1
Coordinates 1570505..1570921 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag P8I08_RS07550 Protein ID WP_001261287.1
Coordinates 1570918..1571148 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I08_RS07530 (1567004) 1567004..1567594 - 591 WP_000194575.1 hypothetical protein -
P8I08_RS07535 (1567594) 1567594..1567851 - 258 WP_000343085.1 hypothetical protein -
P8I08_RS07540 (1568205) 1568205..1570343 + 2139 WP_075322282.1 AAA family ATPase -
P8I08_RS07545 (1570505) 1570505..1570921 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
P8I08_RS07550 (1570918) 1570918..1571148 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
P8I08_RS07555 (1571456) 1571456..1573021 + 1566 WP_000741348.1 AAA family ATPase -
P8I08_RS07560 (1573078) 1573078..1573947 - 870 WP_000253407.1 hypothetical protein -
P8I08_RS07565 (1573949) 1573949..1575037 - 1089 WP_000952231.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaCTX-M-65 - 1548059..1649630 101571


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T275558 WP_001044768.1 NZ_CP121068:c1570921-1570505 [Salmonella enterica subsp. enterica serovar Infantis]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT275558 WP_001261287.1 NZ_CP121068:c1571148-1570918 [Salmonella enterica subsp. enterica serovar Infantis]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References