Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3093869..3094512 Replicon chromosome
Accession NZ_CP121066
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.0914

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag P8I09_RS15180 Protein ID WP_001044768.1
Coordinates 3094096..3094512 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag P8I09_RS15175 Protein ID WP_001261287.1
Coordinates 3093869..3094099 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I09_RS15160 (3089980) 3089980..3091068 + 1089 WP_000952231.1 hypothetical protein -
P8I09_RS15165 (3091070) 3091070..3091939 + 870 WP_000253407.1 hypothetical protein -
P8I09_RS15170 (3091996) 3091996..3093561 - 1566 WP_000741348.1 AAA family ATPase -
P8I09_RS15175 (3093869) 3093869..3094099 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
P8I09_RS15180 (3094096) 3094096..3094512 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
P8I09_RS15185 (3094674) 3094674..3096812 - 2139 WP_075322282.1 AAA family ATPase -
P8I09_RS15190 (3097166) 3097166..3097423 + 258 WP_000343085.1 hypothetical protein -
P8I09_RS15195 (3097423) 3097423..3098013 + 591 WP_000194575.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ant(3'')-Ia / qacE / sul1 / tet(A) - 2913598..3095444 181846


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T275543 WP_001044768.1 NZ_CP121066:3094096-3094512 [Salmonella enterica subsp. enterica serovar Infantis]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT275543 WP_001261287.1 NZ_CP121066:3093869-3094099 [Salmonella enterica subsp. enterica serovar Infantis]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References