Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2359593..2360115 Replicon chromosome
Accession NZ_CP121066
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.0914

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag P8I09_RS11470 Protein ID WP_000221343.1
Coordinates 2359831..2360115 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5X3FYG4
Locus tag P8I09_RS11465 Protein ID WP_000885426.1
Coordinates 2359593..2359841 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I09_RS11435 (2355017) 2355017..2355997 - 981 WP_023993266.1 nitronate monooxygenase -
P8I09_RS11440 (2356171) 2356171..2357079 - 909 WP_242211998.1 LysR family transcriptional regulator -
P8I09_RS11445 (2357985) 2357985..2358431 + 447 Protein_2236 helix-turn-helix domain-containing protein -
P8I09_RS11450 (2358430) 2358430..2358624 - 195 Protein_2237 hypothetical protein -
P8I09_RS11455 (2358904) 2358904..2359236 - 333 WP_000253154.1 DUF1493 family protein -
P8I09_RS11460 (2359226) 2359226..2359441 - 216 WP_023993263.1 phage protein -
P8I09_RS11465 (2359593) 2359593..2359841 + 249 WP_000885426.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P8I09_RS11470 (2359831) 2359831..2360115 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8I09_RS11475 (2360286) 2360286..2360675 + 390 WP_023993262.1 RidA family protein -
P8I09_RS11480 (2360723) 2360723..2361802 - 1080 WP_023993261.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
P8I09_RS11485 (2361995) 2361995..2362483 - 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
P8I09_RS11490 (2362528) 2362528..2364036 + 1509 WP_023993260.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2353288..2366893 13605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T275542 WP_000221343.1 NZ_CP121066:2359831-2360115 [Salmonella enterica subsp. enterica serovar Infantis]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9947

>AT275542 WP_000885426.1 NZ_CP121066:2359593-2359841 [Salmonella enterica subsp. enterica serovar Infantis]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3FYG4

References