Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 3721..4243 Replicon plasmid unnamed2
Accession NZ_CP121005
Organism Salmonella enterica strain 31A

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag P6590_RS23190 Protein ID WP_000220561.1
Coordinates 3721..4002 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag P6590_RS23195 Protein ID WP_000121743.1
Coordinates 3992..4243 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6590_RS23155 574..846 - 273 WP_000167280.1 hypothetical protein -
P6590_RS23160 1079..1258 - 180 WP_000439079.1 hypothetical protein -
P6590_RS23165 1301..1630 - 330 WP_000866654.1 hypothetical protein -
P6590_RS23170 1724..1966 - 243 WP_000008708.1 hypothetical protein -
P6590_RS23175 1956..2225 - 270 WP_001006718.1 hypothetical protein -
P6590_RS23180 2234..2782 - 549 WP_001178641.1 hypothetical protein -
P6590_RS23185 2856..3371 - 516 WP_001025387.1 J domain-containing protein -
P6590_RS23190 3721..4002 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P6590_RS23195 3992..4243 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
P6590_RS23200 5308..6177 + 870 WP_001212191.1 replication initiation protein -
P6590_RS23205 6182..7033 + 852 WP_000435059.1 replication initiation protein -
P6590_RS23210 7037..7483 + 447 WP_001074378.1 hypothetical protein -
P6590_RS23215 7620..7973 + 354 WP_024156393.1 DNA distortion polypeptide 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 - 1..24483 24483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T275533 WP_000220561.1 NZ_CP121005:c4002-3721 [Salmonella enterica]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT275533 WP_000121743.1 NZ_CP121005:c4243-3992 [Salmonella enterica]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References