Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4179224..4180005 Replicon chromosome
Accession NZ_CP121003
Organism Salmonella enterica strain 31A

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag P6590_RS20455 Protein ID WP_000626100.1
Coordinates 4179224..4179715 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag P6590_RS20460 Protein ID WP_001110452.1
Coordinates 4179712..4180005 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6590_RS20420 (4174684) 4174684..4175031 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
P6590_RS20425 (4175007) 4175007..4176710 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
P6590_RS20430 (4176747) 4176747..4177322 + 576 WP_001188509.1 transcriptional regulator -
P6590_RS20440 (4177593) 4177593..4177667 - 75 Protein_3994 helix-turn-helix domain-containing protein -
P6590_RS20445 (4178047) 4178047..4178124 + 78 Protein_3995 porin family protein -
P6590_RS20450 (4178224) 4178224..4178976 + 753 WP_000842433.1 non-specific acid phosphatase -
P6590_RS20455 (4179224) 4179224..4179715 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
P6590_RS20460 (4179712) 4179712..4180005 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
P6590_RS20465 (4180322) 4180322..4180543 + 222 WP_001576552.1 hypothetical protein -
P6590_RS20470 (4180809) 4180809..4181684 + 876 WP_000921676.1 AraC family transcriptional regulator -
P6590_RS20475 (4181681) 4181681..4181968 + 288 WP_001541332.1 transcriptional regulator RtsB -
P6590_RS20480 (4181961) 4181961..4182269 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
P6590_RS20485 (4182268) 4182268..4182516 + 249 Protein_4003 Ig-like domain-containing protein -
P6590_RS20490 (4182628) 4182628..4182759 + 132 Protein_4004 hypothetical protein -
P6590_RS20495 (4183053) 4183053..4183958 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T275529 WP_000626100.1 NZ_CP121003:c4179715-4179224 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT275529 WP_001110452.1 NZ_CP121003:c4180005-4179712 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References