Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4031203..4031753 Replicon chromosome
Accession NZ_CP121003
Organism Salmonella enterica strain 31A

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag P6590_RS19675 Protein ID WP_001199743.1
Coordinates 4031203..4031511 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag P6590_RS19680 Protein ID WP_001118105.1
Coordinates 4031514..4031753 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6590_RS19655 (4027777) 4027777..4028517 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
P6590_RS19660 (4028639) 4028639..4029169 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
P6590_RS19665 (4029492) 4029492..4030625 + 1134 Protein_3844 IS3 family transposase -
P6590_RS19670 (4030657) 4030657..4030797 - 141 Protein_3845 Arm DNA-binding domain-containing protein -
P6590_RS19675 (4031203) 4031203..4031511 - 309 WP_001199743.1 CcdB family protein Toxin
P6590_RS19680 (4031514) 4031514..4031753 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
P6590_RS19685 (4031862) 4031862..4032110 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
P6590_RS19690 (4032187) 4032187..4032732 - 546 WP_223151225.1 helix-turn-helix domain-containing protein -
P6590_RS19700 (4033489) 4033489..4034508 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
P6590_RS19705 (4034536) 4034536..4035066 - 531 WP_000896758.1 gluconokinase -
P6590_RS19710 (4035283) 4035283..4036314 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4029584..4032687 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T275527 WP_001199743.1 NZ_CP121003:c4031511-4031203 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT275527 WP_001118105.1 NZ_CP121003:c4031753-4031514 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References