Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 825015..825675 Replicon chromosome
Accession NZ_CP121003
Organism Salmonella enterica strain 31A

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag P6590_RS03965 Protein ID WP_000244756.1
Coordinates 825262..825675 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag P6590_RS03960 Protein ID WP_000351186.1
Coordinates 825015..825281 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6590_RS03940 (820944) 820944..822377 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
P6590_RS03945 (822535) 822535..822846 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
P6590_RS03950 (823010) 823010..823669 + 660 WP_000250289.1 hemolysin III family protein -
P6590_RS03955 (823785) 823785..824765 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
P6590_RS03960 (825015) 825015..825281 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
P6590_RS03965 (825262) 825262..825675 + 414 WP_000244756.1 protein YgfX Toxin
P6590_RS03970 (825728) 825728..826249 - 522 WP_001055885.1 flavodoxin FldB -
P6590_RS03975 (826362) 826362..827258 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
P6590_RS03980 (827282) 827282..827995 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P6590_RS03985 (828001) 828001..829734 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T275515 WP_000244756.1 NZ_CP121003:825262-825675 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT275515 WP_000351186.1 NZ_CP121003:825015-825281 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References