Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 200172..200932 Replicon chromosome
Accession NZ_CP121003
Organism Salmonella enterica strain 31A

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag P6590_RS00930 Protein ID WP_000533912.1
Coordinates 200447..200932 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag P6590_RS00925 Protein ID WP_000965886.1
Coordinates 200172..200459 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6590_RS00905 (195577) 195577..196488 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
P6590_RS00910 (196498) 196498..198567 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
P6590_RS00915 (198957) 198957..199355 + 399 Protein_181 IS3 family transposase -
P6590_RS00920 (199527) 199527..199994 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
P6590_RS00925 (200172) 200172..200459 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
P6590_RS00930 (200447) 200447..200932 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
P6590_RS00935 (201303) 201303..201842 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
P6590_RS00940 (202016) 202016..202228 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P6590_RS00945 (202516) 202516..202806 - 291 WP_000455790.1 HTH-type transcriptional regulator -
P6590_RS00950 (203245) 203245..203955 + 711 WP_000190524.1 DUF3053 domain-containing protein -
P6590_RS00955 (204005) 204005..204979 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
P6590_RS00960 (205198) 205198..205860 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T275512 WP_000533912.1 NZ_CP121003:200447-200932 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT275512 WP_000965886.1 NZ_CP121003:200172-200459 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References