Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 274250..274958 Replicon plasmid pXJ22MSE1-1
Accession NZ_CP120971
Organism Moellerella wisconsensis strain XJ22MSE1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag P6F44_RS17360 Protein ID WP_241502024.1
Coordinates 274569..274958 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4D7IVZ1
Locus tag P6F44_RS17355 Protein ID WP_067421833.1
Coordinates 274250..274579 (-) Length 110 a.a.

Genomic Context

P6F44_RS17330P6F44_RS17335P6F44_RS17340P6F44_RS17345P6F44_RS17350P6F44_RS17365P6F44_RS17370P6F44_RS17375P6F44_RS17380P6F44_RS17385P6F44_RS17390P6F44_RS17395P6F44_RS17400P6F44_RS17355P6F44_RS17360
Location: 269986..270267 (282 bp)
Type: Others
Protein ID: WP_137022554.1
Location: 270481..271545 (1065 bp)
Type: Others
Protein ID: WP_241502022.1
Location: 271754..272305 (552 bp)
Type: Others
Protein ID: WP_137022556.1
Location: 272393..274042 (1650 bp)
Type: Others
Protein ID: WP_241502023.1
Location: 274029..274211 (183 bp)
Type: Others
Protein ID: WP_137022558.1
Location: 275101..275709 (609 bp)
Type: Others
Protein ID: WP_137022560.1
Location: 275763..276983 (1221 bp)
Type: Others
Protein ID: WP_277850695.1
Location: 277076..277522 (447 bp)
Type: Others
Protein ID: WP_137022562.1
Location: 277567..277707 (141 bp)
Type: Others
Protein ID: WP_175403207.1
Location: 277742..278056 (315 bp)
Type: Others
Protein ID: WP_241502025.1
Location: 278060..278404 (345 bp)
Type: Others
Protein ID: WP_277850696.1
Location: 278502..279332 (831 bp)
Type: Others
Protein ID: WP_277850697.1
Location: 279319..279735 (417 bp)
Type: Others
Protein ID: WP_277850698.1
Location: 274250..274579 (330 bp)
Type: Antitoxin
Protein ID: WP_067421833.1
Location: 274569..274958 (390 bp)
Type: Toxin
Protein ID: WP_241502024.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
P6F44_RS17330269986..270267+282WP_137022554.1hypothetical protein-
P6F44_RS17335270481..271545+1065WP_241502022.1hypothetical protein-
P6F44_RS17340271754..272305+552WP_137022556.1hypothetical protein-
P6F44_RS17345272393..274042+1650WP_241502023.1ATP-binding protein-
P6F44_RS17350274029..274211+183WP_137022558.1hypothetical protein-
P6F44_RS17355274250..274579-330WP_067421833.1helix-turn-helix domain-containing proteinAntitoxin
P6F44_RS17360274569..274958-390WP_241502024.1type II toxin-antitoxin system RelE/ParE family toxinToxin
P6F44_RS17365275101..275709+609WP_137022560.1hypothetical protein-
P6F44_RS17370275763..276983+1221WP_277850695.1hypothetical protein-
P6F44_RS17375277076..277522+447WP_137022562.1hypothetical protein-
P6F44_RS17380277567..277707+141WP_175403207.1hypothetical protein-
P6F44_RS17385277742..278056+315WP_241502025.1hypothetical protein-
P6F44_RS17390278060..278404+345WP_277850696.1hypothetical protein-
P6F44_RS17395278502..279332+831WP_277850697.1TnsA endonuclease N-terminal domain-containing protein-
P6F44_RS17400279319..279735+417WP_277850698.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidlnu(G) / ant(2'')-Ia / catB8 / blaOXA-10 / ant(3'')-Ia / dfrA1 / qacE / sul1 / blaNDM-1 / mph(E) / msr(E) / fosA3 / aph(3')-Ia / qnrA1 / ARR-3 / aac(6')-Ib-cr / floR / aph(4)-Ia / aac(3)-IVa-1..325408325408


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-93)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14451.50 Da        Isoelectric Point: 6.4817

>T275497 WP_241502024.1 NZ_CP120971:c274958-274569 [Moellerella wisconsensis]
VAFYKISSFVRSTKKIPITDKQLLDAAHEVQQGQFEADLGGGVIKKRLAMKGQGKSGSVRVIIFFKINNHLFFADGWTKN
TVNAKGTKEIEDDELETYKKLAAEFLNFDGEIINNLISKGILEEITDEQ

Download         Length: 390 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12062.15 Da        Isoelectric Point: 10.2039

>AT275497 WP_067421833.1 NZ_CP120971:c274579-274250 [Moellerella wisconsensis]
MNNKLNNMLELAKELNAAGASPESLVKDIESTIRAREINDKIKEVSAMSGSEIKMLRTKYCMSQSVLARALGMSKESISK
WERGEKKPSGPALRMLRILESKGPEVLVV

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4D7IVZ1

References