Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 129909..130486 Replicon plasmid pXJ22MSE1-1
Accession NZ_CP120971
Organism Moellerella wisconsensis strain XJ22MSE1

Toxin (Protein)


Gene name mazF Uniprot ID U5N651
Locus tag P6F44_RS16515 Protein ID WP_023159957.1
Coordinates 129909..130241 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U5N340
Locus tag P6F44_RS16520 Protein ID WP_023159984.1
Coordinates 130241..130486 (-) Length 82 a.a.

Genomic Context

P6F44_RS16490P6F44_RS16495P6F44_RS16500P6F44_RS16505P6F44_RS16510P6F44_RS16525P6F44_RS16530P6F44_RS16540P6F44_RS16545P6F44_RS16480P6F44_RS16485P6F44_RS16515P6F44_RS16520P6F44_RS16535
Location: 127223..128029 (807 bp)
Type: Others
Protein ID: WP_277850720.1
Location: 128110..128247 (138 bp)
Type: Others
Protein ID: Protein_160
Location: 128255..128893 (639 bp)
Type: Others
Protein ID: WP_277850716.1
Location: 128909..129538 (630 bp)
Type: Others
Protein ID: WP_241501932.1
Location: 129605..129934 (330 bp)
Type: Others
Protein ID: WP_241501933.1
Location: 130737..131360 (624 bp)
Type: Others
Protein ID: WP_023159958.1
Location: 131493..131720 (228 bp)
Type: Others
Protein ID: WP_048821767.1
Location: 133215..134480 (1266 bp)
Type: Others
Protein ID: WP_277850717.1
Location: 134736..135020 (285 bp)
Type: Others
Protein ID: WP_004917096.1
Location: 125075..125893 (819 bp)
Type: Others
Protein ID: WP_241543873.1
Location: 125909..126862 (954 bp)
Type: Others
Protein ID: WP_166268230.1
Location: 129909..130241 (333 bp)
Type: Toxin
Protein ID: WP_023159957.1
Location: 130241..130486 (246 bp)
Type: Antitoxin
Protein ID: WP_023159984.1
Location: 131812..132573 (762 bp)
Type: Others
Protein ID: WP_241501934.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
P6F44_RS16480125075..125893-819WP_241543873.1DUF4365 domain-containing protein-
P6F44_RS16485125909..126862-954WP_166268230.1site-specific integrase-
P6F44_RS16490127223..128029+807WP_277850720.1type I restriction endonuclease-
P6F44_RS16495128110..128247+138Protein_160HdeA/HdeB family chaperone-
P6F44_RS16500128255..128893+639WP_277850716.1GAD-like domain-containing protein-
P6F44_RS16505128909..129538+630WP_241501932.1GAD-like domain-containing protein-
P6F44_RS16510129605..129934+330WP_241501933.1SMI1/KNR4 family protein-
P6F44_RS16515129909..130241-333WP_023159957.1endoribonuclease MazFToxin
P6F44_RS16520130241..130486-246WP_023159984.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
P6F44_RS16525130737..131360+624WP_023159958.1AAA family ATPase-
P6F44_RS16530131493..131720+228WP_048821767.1plasmid partition protein ParG-
P6F44_RS16535131812..132573-762WP_241501934.1IS5 family transposase-
P6F44_RS16540133215..134480+1266WP_277850717.1integrase arm-type DNA-binding domain-containing protein-
P6F44_RS16545134736..135020+285WP_004917096.1membrane protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidlnu(G) / ant(2'')-Ia / catB8 / blaOXA-10 / ant(3'')-Ia / dfrA1 / qacE / sul1 / blaNDM-1 / mph(E) / msr(E) / fosA3 / aph(3')-Ia / qnrA1 / ARR-3 / aac(6')-Ib-cr / floR / aph(4)-Ia / aac(3)-IVa-1..325408325408


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12097.88 Da        Isoelectric Point: 7.0813

>T275496 WP_023159957.1 NZ_CP120971:c130241-129909 [Moellerella wisconsensis]
MVSRYVPDSGDLIWIDFDPVEGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTKGKGYPFECELSNERDSYALADQVTCV
DWRARKVTKKGKVEASELAEIKAKAKALIG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8786.20 Da        Isoelectric Point: 5.0351

>AT275496 WP_023159984.1 NZ_CP120971:c130486-130241 [Moellerella wisconsensis]
MAQVTVKKWGNSPSVRLPVAIMQKAALSVDDTVEIAVEEGRIIITPVKAVEYSLDNLLAGITPENIHEKVDFGARTGKEL
I

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2P1BQ75

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A857E7M9

References