Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3941377..3942011 Replicon chromosome
Accession NZ_CP120969
Organism Pseudomonas putida strain AHSWHJXPP1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P3X84_RS18560 Protein ID WP_020308731.1
Coordinates 3941377..3941781 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L1LS63
Locus tag P3X84_RS18565 Protein ID WP_003285520.1
Coordinates 3941781..3942011 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3X84_RS18540 (P3X84_18540) 3936515..3937606 - 1092 WP_144188584.1 hypothetical protein -
P3X84_RS18545 (P3X84_18545) 3938368..3939783 + 1416 WP_074859153.1 YfjI family protein -
P3X84_RS18550 (P3X84_18550) 3939895..3940224 + 330 WP_023101967.1 hypothetical protein -
P3X84_RS18555 (P3X84_18555) 3940322..3941290 + 969 WP_256825339.1 DUF932 domain-containing protein -
P3X84_RS18560 (P3X84_18560) 3941377..3941781 - 405 WP_020308731.1 tRNA(fMet)-specific endonuclease VapC Toxin
P3X84_RS18565 (P3X84_18565) 3941781..3942011 - 231 WP_003285520.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
P3X84_RS18570 (P3X84_18570) 3942168..3943172 + 1005 WP_256825338.1 YqaJ viral recombinase family protein -
P3X84_RS18575 (P3X84_18575) 3943264..3944214 + 951 WP_144189643.1 hydrolase or metal-binding protein -
P3X84_RS18580 (P3X84_18580) 3944186..3944683 + 498 WP_144188592.1 DNA repair protein RadC -
P3X84_RS18585 (P3X84_18585) 3944694..3944867 + 174 WP_165362587.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3920864..3943172 22308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-35)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14995.23 Da        Isoelectric Point: 7.2774

>T275489 WP_020308731.1 NZ_CP120969:c3941781-3941377 [Pseudomonas putida]
MLKYMLDTNMCIFTIKNRPEQVREAFKRHSGQLSISTVTLMELIYGAEKSANPERNLADVEGFAARLEVLPYDAQAAAHS
GQLRAELARIGKPIGPYDQMIAGHARAQGLILVTNNLREFERVPGLRVEDWVNA

Download         Length: 405 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8432.41 Da        Isoelectric Point: 4.2683

>AT275489 WP_003285520.1 NZ_CP120969:c3942011-3941781 [Pseudomonas putida]
MEQGAVFQSNRSQAVRLPKAVALPEDVKRVDVVVVGRARIITPAGEAWDVWFDGEGVTADYMADREQPADQERDAF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L1LS63

References