Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-higA/HigB-HigA
Location 340026..341017 Replicon chromosome
Accession NZ_CP120969
Organism Pseudomonas putida strain AHSWHJXPP1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag P3X84_RS01505 Protein ID WP_232435437.1
Coordinates 340026..340502 (+) Length 159 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q88R60
Locus tag P3X84_RS01510 Protein ID WP_004575922.1
Coordinates 340544..341017 (+) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3X84_RS01485 (P3X84_01485) 335067..336434 - 1368 WP_060539158.1 ATP-binding protein -
P3X84_RS01490 (P3X84_01490) 336436..337155 - 720 WP_004575925.1 response regulator -
P3X84_RS01495 (P3X84_01495) 337296..339593 + 2298 WP_003255779.1 TonB-dependent siderophore receptor -
P3X84_RS01500 (P3X84_01500) 339761..339967 - 207 WP_003255778.1 DUF3079 domain-containing protein -
P3X84_RS01505 (P3X84_01505) 340026..340502 + 477 WP_232435437.1 type II toxin-antitoxin system HigB family toxin Toxin
P3X84_RS01510 (P3X84_01510) 340544..341017 + 474 WP_004575922.1 transcriptional regulator Antitoxin
P3X84_RS01515 (P3X84_01515) 341022..341235 - 214 Protein_292 integrase -
P3X84_RS01520 (P3X84_01520) 341438..341680 + 243 WP_232435436.1 type II toxin-antitoxin system RelE/ParE family toxin -
P3X84_RS01525 (P3X84_01525) 341639..341797 - 159 Protein_294 transcriptional regulator -
P3X84_RS01530 (P3X84_01530) 341792..342007 - 216 Protein_295 integrase -
P3X84_RS01535 (P3X84_01535) 341995..342354 + 360 Protein_296 phage portal protein -
P3X84_RS01540 (P3X84_01540) 342368..342721 - 354 WP_146051591.1 hypothetical protein -
P3X84_RS01545 (P3X84_01545) 342970..343512 - 543 WP_004575918.1 ImmA/IrrE family metallo-endopeptidase -
P3X84_RS01550 (P3X84_01550) 344090..345013 - 924 WP_259537442.1 IS3 family transposase -
P3X84_RS01555 (P3X84_01555) 345010..345303 - 294 WP_060537279.1 transposase -
P3X84_RS01560 (P3X84_01560) 345566..346000 - 435 WP_004577124.1 DUF4145 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(114-152)

Antitoxin

Antitoxin HigA

(43-154)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18459.43 Da        Isoelectric Point: 10.2237

>T275485 WP_232435437.1 NZ_CP120969:340026-340502 [Pseudomonas putida]
MTGINPLAIARSPYIAHPDIWLTDIWIRDIFHPMLVRRDNTMRVITKAAVTKAIEAHGQWKAPLSLWLTTFDRATLRFES
FEQLRQTWVTVSGWSVDRIPHSELRPASRKGPLDIYVFDIKKNECRLIAWLNARTGTLYIKAILSHAEYDKWCRSDIR

Download         Length: 477 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17229.67 Da        Isoelectric Point: 4.4982

>AT275485 WP_004575922.1 NZ_CP120969:340544-341017 [Pseudomonas putida]
MKRDKIEANGLDAFIANISPMLDGLNTQMATMAQLLAACHDPIKDDAELEARMALIDELYSHADSEGHAAARFAEMVADR
VYEYESESVLVPFASQAEALAFLLSDRGVKQKDLSAIATQSAVSEILNNKRKMTVAQIKGFAEFFSVPVEFFMHGVV

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2I0CBJ4

References