Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2334711..2335689 Replicon chromosome
Accession NZ_CP120958
Organism Bacillus cereus strain SCBCM001

Toxin (Protein)


Gene name spoIISA Uniprot ID W8Y388
Locus tag P4G50_RS12010 Protein ID WP_000624977.1
Coordinates 2334711..2335448 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID M1PKC2
Locus tag P4G50_RS12015 Protein ID WP_000237819.1
Coordinates 2335561..2335689 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4G50_RS11990 2330354..2331136 + 783 WP_065212733.1 class I SAM-dependent methyltransferase -
P4G50_RS11995 2331294..2332979 - 1686 WP_195862588.1 alpha-keto acid decarboxylase family protein -
P4G50_RS12000 2333087..2333569 + 483 WP_000191888.1 MarR family winged helix-turn-helix transcriptional regulator -
P4G50_RS12005 2333735..2334472 + 738 WP_000594152.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
P4G50_RS12010 2334711..2335448 + 738 WP_000624977.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
P4G50_RS12015 2335561..2335689 + 129 WP_000237819.1 hypothetical protein Antitoxin
P4G50_RS12020 2335762..2335938 + 177 WP_000852629.1 stage II sporulation protein SB -
P4G50_RS12025 2335958..2336347 - 390 WP_000713863.1 YxeA family protein -
P4G50_RS12030 2336559..2338028 + 1470 WP_000287556.1 beta-Ala-His dipeptidase -
P4G50_RS12035 2338274..2339083 + 810 WP_000678370.1 papain-like cysteine protease family protein -
P4G50_RS12040 2339109..2339711 + 603 WP_139846814.1 hypothetical protein -
P4G50_RS12045 2339955..2340206 - 252 WP_000827560.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28307.03 Da        Isoelectric Point: 8.2998

>T275484 WP_000624977.1 NZ_CP120958:2334711-2335448 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4953.36 Da        Isoelectric Point: 3.9798

>AT275484 WP_000237819.1 NZ_CP120958:2335561-2335689 [Bacillus cereus]
VVKDYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W8Y388

Antitoxin

Source ID Structure
AlphaFold DB M1PKC2

References