Detailed information of TA system TA275480

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4309411..4310120
• Replicon: chromosome
• Accession: NZ_CP120956
• Organism: Delftia tsuruhatensis strain Ery-6A

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: PYR84_RS19585
• Protein ID: WP_277848642.1
• Coordinates: 4309674..4310120 (+)
• Length: 149 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1D8IU58
• Locus tag: PYR84_RS19580
• Protein ID: WP_016453264.1
• Coordinates: 4309411..4309677 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PYR84_RS19560 (PYR84_19560)	4304777..4306408	+	1632	WP_277848639.1	gamma-glutamyltransferase family protein	-
PYR84_RS19565 (PYR84_19565)	4306432..4307427	-	996	WP_277848640.1	tripartite tricarboxylate transporter substrate binding protein	-
PYR84_RS19570 (PYR84_19570)	4307454..4308338	-	885	WP_277848641.1	amidohydrolase family protein	-
PYR84_RS19575 (PYR84_19575)	4308415..4309386	+	972	WP_046988493.1	LysR family transcriptional regulator	-
PYR84_RS19580 (PYR84_19580)	4309411..4309677	+	267	WP_016453264.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
PYR84_RS19585 (PYR84_19585)	4309674..4310120	+	447	WP_277848642.1	type II toxin-antitoxin system VapC family toxin	Toxin
PYR84_RS19590 (PYR84_19590)	4310184..4311389	+	1206	WP_047326878.1	MFS transporter	-
PYR84_RS19595 (PYR84_19595)	4311468..4312097	+	630	WP_277848643.1	DUF4124 domain-containing protein	-
PYR84_RS19600 (PYR84_19600)	4312161..4313306	-	1146	WP_277848645.1	ABC transporter permease	-
PYR84_RS19605 (PYR84_19605)	4313308..4314522	-	1215	WP_277848646.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-133)

Antitoxin

• SpoVT-AbrB domain (8-54)

Sequences

Toxin

Protein

• Length: 149 a.a.
• Molecular weight: 15824.39 Da
• Isoelectric Point: 8.1045

>T275480 WP_277848642.1 NZ_CP120956:4309674-4310120 [Delftia tsuruhatensis]
MTRYLLDTNIASHIIKGDIAAVREQLVRVPMHQIAVSAVTQAELMYGVAKRGHPAGLSLRVTGFLARVEVLPWTAQVADA
YGHLRAACEAAGITLASMDMMIAAHALLLQQQAAQAGERSVLVTRDRVFSRIPEPGLAIADWTTGPAG

Nucleotide

• Length: 447 bp

>T275480 NZ_CP120956:4309674-4310120 [Delftia tsuruhatensis]
ATGACACGCTACCTGCTGGACACCAACATCGCCAGCCACATCATCAAAGGCGATATCGCTGCCGTGCGCGAACAGCTGGT
TCGCGTACCCATGCACCAGATCGCAGTGTCGGCGGTCACGCAGGCCGAACTGATGTACGGGGTCGCCAAGCGCGGCCACC
CTGCCGGGCTGTCGCTGCGGGTGACAGGGTTCCTGGCCCGCGTCGAGGTGCTGCCCTGGACGGCCCAGGTGGCCGATGCC
TACGGCCACCTGCGCGCCGCCTGCGAGGCGGCCGGCATCACGCTGGCCTCCATGGACATGATGATTGCCGCGCACGCCCT
GCTCCTGCAGCAGCAGGCCGCGCAGGCCGGCGAGCGCTCGGTGCTGGTCACAAGAGACCGGGTGTTCAGCCGCATTCCCG
AACCCGGACTGGCCATCGCGGACTGGACCACCGGCCCGGCTGGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10046.05 Da
• Isoelectric Point: 4.3846

>AT275480 WP_016453264.1 NZ_CP120956:4309411-4309677 [Delftia tsuruhatensis]
VTQTAKLFTTGRSQAVRLPYEFRFEEKEVYIRRDPVTGDVILSRRPDSWQEFFALDATTDVPADFMDTADRAQPESGRDP
FADEGSAR

Nucleotide

• Length: 267 bp

>AT275480 NZ_CP120956:4309411-4309677 [Delftia tsuruhatensis]
GTGACGCAGACTGCCAAGCTTTTCACCACCGGTCGCAGCCAGGCCGTGCGCCTTCCCTATGAATTCCGGTTCGAGGAAAA
AGAGGTCTACATACGTCGCGACCCCGTCACGGGCGACGTGATCCTGTCGCGCCGTCCCGACTCATGGCAAGAGTTCTTTG
CGCTCGACGCCACCACCGACGTGCCGGCCGATTTCATGGACACCGCTGACCGAGCGCAGCCAGAGTCAGGCCGCGATCCG
TTTGCCGACGAAGGCAGTGCGCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A1D8IU58