Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1018274..1018869 Replicon chromosome
Accession NZ_CP120949
Organism Burkholderia contaminans strain 5080

Toxin (Protein)


Gene name chpB Uniprot ID A0A1E3FP25
Locus tag P4E65_RS36445 Protein ID WP_039362634.1
Coordinates 1018274..1018624 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A0G3Z282
Locus tag P4E65_RS36450 Protein ID WP_039362633.1
Coordinates 1018618..1018869 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4E65_RS36435 (P4E65_36435) 1015129..1016589 + 1461 WP_039362635.1 efflux RND transporter periplasmic adaptor subunit -
P4E65_RS36440 (P4E65_36440) 1016621..1018150 + 1530 WP_039362750.1 efflux transporter outer membrane subunit -
P4E65_RS36445 (P4E65_36445) 1018274..1018624 - 351 WP_039362634.1 type II toxin-antitoxin system ChpB family toxin Toxin
P4E65_RS36450 (P4E65_36450) 1018618..1018869 - 252 WP_039362633.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
P4E65_RS36455 (P4E65_36455) 1019402..1021222 + 1821 WP_046197074.1 asparagine synthase (glutamine-hydrolyzing) -
P4E65_RS36460 (P4E65_36460) 1021454..1022914 - 1461 WP_039362631.1 heavy metal sensor histidine kinase -
P4E65_RS36465 (P4E65_36465) 1022911..1023588 - 678 WP_039362629.1 heavy metal response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12403.30 Da        Isoelectric Point: 10.0752

>T275474 WP_039362634.1 NZ_CP120949:c1018624-1018274 [Burkholderia contaminans]
MVRRVKFERGDIVRVSLNPTVGKEQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARYAGFAVPLSGSGTETQGVALV
NMVRTLDLQARGARKVERAPSEVIEDALARLQTILE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8948.19 Da        Isoelectric Point: 4.7204

>AT275474 WP_039362633.1 NZ_CP120949:c1018869-1018618 [Burkholderia contaminans]
MELKIQKWGNSAAVRLPAVLLEQIDASVGSSLNADVRPDGVLLSPARRKYSLDELIAQCDPKAPEPADLAAWGESKPVGH
EAW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FP25

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3Z282

References