Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2366457..2367098 Replicon chromosome
Accession NZ_CP120948
Organism Burkholderia contaminans strain 5080

Toxin (Protein)


Gene name relE Uniprot ID A0A1E3FZX6
Locus tag P4E65_RS28005 Protein ID WP_039344753.1
Coordinates 2366457..2366795 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1J9PWC2
Locus tag P4E65_RS28010 Protein ID WP_039344756.1
Coordinates 2366799..2367098 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4E65_RS27995 (P4E65_27995) 2363022..2364455 - 1434 WP_039344747.1 aldehyde dehydrogenase family protein -
P4E65_RS28000 (P4E65_28000) 2364485..2366125 - 1641 WP_039344750.1 acetolactate synthase large subunit -
P4E65_RS28005 (P4E65_28005) 2366457..2366795 + 339 WP_039344753.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P4E65_RS28010 (P4E65_28010) 2366799..2367098 + 300 WP_039344756.1 putative addiction module antidote protein Antitoxin
P4E65_RS28015 (P4E65_28015) 2367147..2368433 - 1287 WP_039344759.1 DUF445 domain-containing protein -
P4E65_RS28020 (P4E65_28020) 2368604..2369824 - 1221 WP_039344761.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
P4E65_RS28025 (P4E65_28025) 2369814..2370140 - 327 WP_039344765.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
P4E65_RS28030 (P4E65_28030) 2370161..2370649 - 489 WP_011355917.1 anthranilate 1,2-dioxygenase small subunit AndAd -
P4E65_RS28035 (P4E65_28035) 2370664..2371935 - 1272 WP_039344770.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(16-107)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12583.47 Da        Isoelectric Point: 9.5691

>T275473 WP_039344753.1 NZ_CP120948:2366457-2366795 [Burkholderia contaminans]
MVDILQSMPYSAPTFSIRTTGVFDTWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRG
TIWVILLCGGDKSSQQADIRAAHAMLAHLDME

Download         Length: 339 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10649.01 Da        Isoelectric Point: 6.3217

>AT275473 WP_039344756.1 NZ_CP120948:2366799-2367098 [Burkholderia contaminans]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FZX6

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9PWC2

References