Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1498726..1499365 Replicon chromosome
Accession NZ_CP120948
Organism Burkholderia contaminans strain 5080

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P4E65_RS24200 Protein ID WP_223274309.1
Coordinates 1498949..1499365 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1PQC0
Locus tag P4E65_RS24195 Protein ID WP_039351245.1
Coordinates 1498726..1498962 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4E65_RS24180 (P4E65_24180) 1494508..1496088 + 1581 WP_039350882.1 FadD3 family acyl-CoA ligase -
P4E65_RS24185 (P4E65_24185) 1496127..1496900 + 774 WP_039351252.1 SDR family oxidoreductase -
P4E65_RS24190 (P4E65_24190) 1497693..1498352 + 660 WP_046196544.1 hypothetical protein -
P4E65_RS24195 (P4E65_24195) 1498726..1498962 + 237 WP_039351245.1 DNA-binding protein Antitoxin
P4E65_RS24200 (P4E65_24200) 1498949..1499365 + 417 WP_223274309.1 type II toxin-antitoxin system VapC family toxin Toxin
P4E65_RS24205 (P4E65_24205) 1499565..1500461 + 897 WP_039350875.1 VOC family protein -
P4E65_RS24210 (P4E65_24210) 1500471..1501364 + 894 WP_039350872.1 CoA-transferase -
P4E65_RS24215 (P4E65_24215) 1501375..1502172 + 798 WP_039350869.1 ketoacid CoA transferase -
P4E65_RS24220 (P4E65_24220) 1502181..1503113 + 933 WP_039350867.1 enoyl-CoA hydratase -
P4E65_RS24225 (P4E65_24225) 1503110..1504198 + 1089 WP_039350864.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15370.68 Da        Isoelectric Point: 7.4021

>T275471 WP_223274309.1 NZ_CP120948:1498949-1499365 [Burkholderia contaminans]
VYLIDTNIISEIRKGKRTNRGVRAFFRQAAADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATILSGYAPNI
LPVDIEISQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVEDFARTGVKLLNPFD

Download         Length: 417 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8598.61 Da        Isoelectric Point: 5.0477

>AT275471 WP_039351245.1 NZ_CP120948:1498726-1498962 [Burkholderia contaminans]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILADALGRPKRKTFAQVLMSMPDVGDDADFQRVQDSGEARRVFD

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1PQC0

References