Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 186038..186557 Replicon chromosome
Accession NZ_CP120948
Organism Burkholderia contaminans strain 5080

Toxin (Protein)


Gene name relE Uniprot ID A0A1E3FLI5
Locus tag P4E65_RS18460 Protein ID WP_039349649.1
Coordinates 186276..186557 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4V2WFY1
Locus tag P4E65_RS18455 Protein ID WP_039349647.1
Coordinates 186038..186286 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4E65_RS18445 (P4E65_18445) 183470..184660 + 1191 WP_039349643.1 2-methylaconitate cis-trans isomerase PrpF -
P4E65_RS18450 (P4E65_18450) 184844..185896 + 1053 WP_039349645.1 CaiB/BaiF CoA-transferase family protein -
P4E65_RS18455 (P4E65_18455) 186038..186286 + 249 WP_039349647.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P4E65_RS18460 (P4E65_18460) 186276..186557 + 282 WP_039349649.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P4E65_RS18465 (P4E65_18465) 186675..187118 - 444 WP_011353771.1 PaaI family thioesterase -
P4E65_RS18470 (P4E65_18470) 187388..189007 + 1620 WP_039349654.1 methyl-accepting chemotaxis protein -
P4E65_RS18475 (P4E65_18475) 188980..190089 - 1110 WP_039349656.1 AGE family epimerase/isomerase -
P4E65_RS18480 (P4E65_18480) 190203..190901 + 699 WP_039349658.1 MgtC/SapB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10986.88 Da        Isoelectric Point: 10.7091

>T275469 WP_039349649.1 NZ_CP120948:186276-186557 [Burkholderia contaminans]
MTFELAFLEPALKEWKKLDRTVRDQFKSRLAERLENPRIPSAKLQGHPDRYKIKLRSVGYRLVYEVRDSEVLVLVVAVGR
RERDAVYLAAMKR

Download         Length: 282 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9031.44 Da        Isoelectric Point: 5.6792

>AT275469 WP_039349647.1 NZ_CP120948:186038-186286 [Burkholderia contaminans]
MPHTILANVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADKRAKEKVVKVKLN
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FLI5

Antitoxin

Source ID Structure
AlphaFold DB A0A4V2WFY1

References