Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VagC(antitoxin)
Location 1929412..1929836 Replicon chromosome
Accession NZ_CP120947
Organism Burkholderia contaminans strain 5080

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag P4E65_RS08860 Protein ID WP_223274361.1
Coordinates 1929675..1929836 (+) Length 54 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1E3FFT1
Locus tag P4E65_RS08855 Protein ID WP_046196769.1
Coordinates 1929412..1929678 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4E65_RS08840 (P4E65_08840) 1924959..1927220 + 2262 WP_039358640.1 TonB-dependent siderophore receptor -
P4E65_RS08845 (P4E65_08845) 1927307..1928146 + 840 WP_039358638.1 N(5)-hydroxyornithine transformylase PvdF -
P4E65_RS08850 (P4E65_08850) 1928146..1929162 + 1017 WP_039358635.1 GNAT family N-acetyltransferase -
P4E65_RS08855 (P4E65_08855) 1929412..1929678 + 267 WP_046196769.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
P4E65_RS08860 (P4E65_08860) 1929675..1929836 + 162 WP_223274361.1 type II toxin-antitoxin system VapC family toxin Toxin
P4E65_RS08865 (P4E65_08865) 1929864..1930091 + 228 WP_223274360.1 hypothetical protein -
P4E65_RS08870 (P4E65_08870) 1930140..1930379 - 240 Protein_1726 nucleotidyltransferase -
P4E65_RS08875 (P4E65_08875) 1930393..1931481 - 1089 WP_249215684.1 type IV toxin-antitoxin system AbiEi family antitoxin -
P4E65_RS08880 (P4E65_08880) 1931801..1932964 + 1164 WP_039358627.1 M20 aminoacylase family protein -
P4E65_RS08885 (P4E65_08885) 1933081..1933326 + 246 WP_076841742.1 type II toxin-antitoxin system ParD family antitoxin -
P4E65_RS08890 (P4E65_08890) 1933372..1933611 + 240 WP_232490759.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 5903.95 Da        Isoelectric Point: 8.5349

>T275467 WP_223274361.1 NZ_CP120947:1929675-1929836 [Burkholderia contaminans]
VTTLYMLDTSICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAAG

Download         Length: 162 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9629.86 Da        Isoelectric Point: 4.4819

>AT275467 WP_046196769.1 NZ_CP120947:1929412-1929678 [Burkholderia contaminans]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTCLSFASEPPADADFLAERPAVIEPGRFDLSDGGG
AAPTESGQ

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1E3FFT1

References