Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 178250..178887 Replicon chromosome
Accession NZ_CP120947
Organism Burkholderia contaminans strain 5080

Toxin (Protein)


Gene name vapC Uniprot ID A0A228K4S8
Locus tag P4E65_RS00735 Protein ID WP_039351354.1
Coordinates 178486..178887 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1E3FXY0
Locus tag P4E65_RS00730 Protein ID WP_039351357.1
Coordinates 178250..178486 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4E65_RS00715 (P4E65_00715) 173943..174974 + 1032 WP_039351365.1 helix-turn-helix domain-containing protein -
P4E65_RS00720 (P4E65_00720) 175092..176189 - 1098 WP_039351363.1 ADP-heptose--LPS heptosyltransferase -
P4E65_RS00725 (P4E65_00725) 176186..177889 - 1704 WP_039351360.1 thiamine pyrophosphate-binding protein -
P4E65_RS00730 (P4E65_00730) 178250..178486 + 237 WP_039351357.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
P4E65_RS00735 (P4E65_00735) 178486..178887 + 402 WP_039351354.1 type II toxin-antitoxin system VapC family toxin Toxin
P4E65_RS00740 (P4E65_00740) 178958..180346 - 1389 WP_039351351.1 L-serine ammonia-lyase -
P4E65_RS00745 (P4E65_00745) 180377..181480 - 1104 WP_223274380.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14880.98 Da        Isoelectric Point: 4.7249

>T275466 WP_039351354.1 NZ_CP120947:178486-178887 [Burkholderia contaminans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVAACASPARERGNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLDD

Download         Length: 402 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9008.13 Da        Isoelectric Point: 6.4720

>AT275466 WP_039351357.1 NZ_CP120947:178250-178486 [Burkholderia contaminans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTRVLEKFAKFGPDFMADGRGDHEQADREGL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228K4S8

Antitoxin

Source ID Structure
AlphaFold DB A0A1E3FXY0

References