Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4858726..4859321 Replicon chromosome
Accession NZ_CP120944
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag P7249_RS24320 Protein ID WP_000239579.1
Coordinates 4858726..4859076 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag P7249_RS24325 Protein ID WP_001223210.1
Coordinates 4859070..4859321 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7249_RS24300 (4854172) 4854172..4855194 - 1023 WP_001301928.1 ABC transporter permease -
P7249_RS24305 (4855208) 4855208..4856710 - 1503 WP_000205806.1 sugar ABC transporter ATP-binding protein -
P7249_RS24310 (4856850) 4856850..4857806 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
P7249_RS24315 (4858116) 4858116..4858646 + 531 WP_000055075.1 inorganic diphosphatase -
P7249_RS24320 (4858726) 4858726..4859076 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
P7249_RS24325 (4859070) 4859070..4859321 - 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
P7249_RS24330 (4859533) 4859533..4859874 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
P7249_RS24335 (4859877) 4859877..4863656 - 3780 WP_000060930.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T275463 WP_000239579.1 NZ_CP120944:c4859076-4858726 [Escherichia coli O157:H7 str. EDL933]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT275463 WP_001223210.1 NZ_CP120944:c4859321-4859070 [Escherichia coli O157:H7 str. EDL933]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure

References