275460

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4609438..4609988 Replicon chromosome
Accession NZ_CP120944
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag P7249_RS23260 Protein ID WP_001160975.1
Coordinates 4609438..4609752 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag P7249_RS23265 Protein ID WP_000125566.1
Coordinates 4609755..4609988 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7249_RS23235 (4605113) 4605113..4606399 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
P7249_RS23240 (4606399) 4606399..4607388 + 990 WP_000241259.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
P7249_RS23245 (4607385) 4607385..4608206 + 822 WP_001065380.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
P7249_RS23250 (4608209) 4608209..4608586 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
P7249_RS23255 (4608593) 4608593..4609441 + 849 WP_000257187.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
P7249_RS23260 (4609438) 4609438..4609752 - 315 WP_001160975.1 CcdB family protein Toxin
P7249_RS23265 (4609755) 4609755..4609988 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
P7249_RS23270 (4610074) 4610074..4610553 - 480 WP_000624372.1 type 3 dihydrofolate reductase -
P7249_RS23275 (4610745) 4610745..4612607 - 1863 WP_000377184.1 glutathione-regulated potassium-efflux system protein KefC -
P7249_RS23280 (4612600) 4612600..4613130 - 531 WP_000600700.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
P7249_RS23285 (4613238) 4613238..4614569 - 1332 WP_001183177.1 MFS transporter -
P7249_RS23290 (4614627) 4614627..4614914 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T275460 WP_001160975.1 NZ_CP120944:c4609752-4609438 [Escherichia coli O157:H7 str. EDL933]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT275460 WP_000125566.1 NZ_CP120944:c4609988-4609755 [Escherichia coli O157:H7 str. EDL933]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References