275458

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4118016..4118634 Replicon chromosome
Accession NZ_CP120944
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P7249_RS20950 Protein ID WP_001291435.1
Coordinates 4118416..4118634 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P7249_RS20945 Protein ID WP_000344800.1
Coordinates 4118016..4118390 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7249_RS20935 (4113105) 4113105..4114298 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P7249_RS20940 (4114321) 4114321..4117470 + 3150 WP_001132452.1 efflux RND transporter permease AcrB -
P7249_RS20945 (4118016) 4118016..4118390 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P7249_RS20950 (4118416) 4118416..4118634 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P7249_RS20955 (4118806) 4118806..4119357 + 552 WP_000102553.1 maltose O-acetyltransferase -
P7249_RS20960 (4119473) 4119473..4119943 + 471 WP_000136192.1 YlaC family protein -
P7249_RS20965 (4120107) 4120107..4121657 + 1551 WP_001301851.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P7249_RS20970 (4121699) 4121699..4122052 - 354 WP_000878140.1 DUF1428 domain-containing protein -
P7249_RS20980 (4122431) 4122431..4122742 + 312 WP_000409911.1 MGMT family protein -
P7249_RS20985 (4122775) 4122775..4123347 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T275458 WP_001291435.1 NZ_CP120944:4118416-4118634 [Escherichia coli O157:H7 str. EDL933]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT275458 WP_000344800.1 NZ_CP120944:4118016-4118390 [Escherichia coli O157:H7 str. EDL933]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References